Network representation of protein interactions: Theory of graph description and analysis.

ABSTRACT: A methodological framework is presented for the graph theoretical interpretation of NMR data of protein interactions. The proposed analysis generalizes the idea of network representations of protein structures by expanding it to protein interactions. This approach is based on regularization of residue-resolved NMR relaxation times and chemical shift data and subsequent construction of an adjacency matrix that represents the underlying protein interaction as a graph or network. The network nodes represent protein residues. Two nodes are connected if two residues are functionally correlated during the protein interaction event. The analysis of the resulting network enables the quantification of the importance of each amino acid of a protein for its interactions. Furthermore, the determinatio

SUBMITTER: Kurzbach D 

PROVIDER: S-EPMC5338233 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature