Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution.

ABSTRACT: Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T₁ of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d<

SUBMITTER: Burueva DB 

PROVIDER: S-EPMC5338591 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature