A Randomized Crossover Trial of Dietary Sodium Restriction in Stage 3-4 CKD.

ABSTRACT:

Background and objectives

Patients with chronic kidney disease (CKD) are often volume expanded and hypertensive. Few controlled studies have assessed the effects of a sodium-restricted diet (SRD) in CKD.

Design, setting, participants, & measurements

We conducted a randomized crossover trial to evaluate the effect of SRD (target <2 g sodium per day) versus usual diet on hydration status (by bioelectrical impedance spectroscopy) and blood pressure (BP) between May of 2009 and May of 2013. A total of 58 adults with stage 3-4 CKD were enrolled from two academic sites: University of Michigan (n=37) and University of North Carolina at Chapel Hill (n=21); 60% were men, 43% were diabetic, 93% were hypertensive, and mean age was 61 years. Participants followed SRD or us

SUBMITTER: Saran R 

PROVIDER: S-EPMC5338699 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature