Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP₃ Receptors in the Induction of Hyperalgesic Priming.

ABSTRACT: Hyperalgesic priming, a model of pain chronification in the rat, is mediated by ryanodine receptor-dependent calcium release. Although ryanodine induces priming in both sexes, females are 5 orders of magnitude more sensitive, by an estrogen receptor α (EsRα)-dependent mechanism. An inositol 1,4,5-triphosphate (IP₃) receptor inhibitor prevented the induction of priming by ryanodine. For IP₃ induced priming, females were also more sensitive. IP₃-induced priming was prevented by pretreatment with inhibitors of the sarcoendoplasmic reticulum calcium ATPase and ryanodine receptor. Antisense to EsRα prevented the induction of priming by low-dose IP₃ in females. The induction of priming by an EsRα agonist was ryanodine receptor-dependent and prevented b

SUBMITTER: Khomula EV 

PROVIDER: S-EPMC5338754 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature