Cognitive change trajectories in virally suppressed HIV-infected individuals indicate high prevalence of disease activity.

ABSTRACT:

Background

The longitudinal rate and profile of cognitive decline in persons with stable, treated, and virally suppressed HIV infection is not established. To address this question, the current study quantifies the rate of cognitive decline in a cohort of virally suppressed HIV+ persons using clinically relevant definitions of decline, and determine cognitive trajectories taking into account historical and baseline HAND status.

Methods

Ninety-six HIV+ (clinically stable and virally undetectable) and 44 demographically comparable HIV- participants underwent standard neuropsychological testing at baseline and 18-months follow-up. We described clinically relevant cognitive trajectories based on standard definitions of historical and baseline HAND status and cognitive decline. H

SUBMITTER: Gott C 

PROVIDER: S-EPMC5338778 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature