In vivo T2* weighted MRI visualizes cardiac lesions in murine models of acute and chronic viral myocarditis.

ABSTRACT:

Objective

Acute and chronic forms of myocarditis are mainly induced by virus infections. As a consequence of myocardial damage and inflammation dilated cardiomyopathy and chronic heart failure may develop. The gold standard for the diagnosis of myocarditis is endomyocardial biopsies which are required to determine the etiopathogenesis of cardiac inflammatory processes. However, new non-invasive MRI techniques hold great potential in visualizing cardiac non-ischemic inflammatory lesions at high spatial resolution, which could improve the investigation of the pathophysiology of viral myocarditis.

Results

Here we present the discovery of a novel endogenous T2* MRI contrast of myocardial lesions in murine models of acute and chronic CVB3 myocarditis. The evaluation of infected h

SUBMITTER: Helluy X 

PROVIDER: S-EPMC5338786 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature