Increasing risk of cataract in HCV patients receiving anti-HCV therapy: A nationwide cohort study.

ABSTRACT:

Purpose

Hepatitis C virus (HCV) infection is associated with increased systemic oxidative stress, which leads to cardiovascular events, diabetes, and chronic kidney disease. Similarly, cataract is also associated with increased oxidative stress. The association between HCV infection and increased risk of cataract remains unclear.

Methods

A total of 11,652 HCV-infected patients and 46,608 age- and sex-matched non-HCV infected patients were identified during 2003-2011. All patient data were tracked until a diagnosis of cataract, death, or the end of 2011. Cumulative incidences and hazard ratios (HRs) were calculated.

Results

The mean follow-up durations were 5.29 and 5.86 years for the HCV and non-HCV cohorts, respectively. The overall incidence density rate for catarac

SUBMITTER: Lin SY 

PROVIDER: S-EPMC5338813 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature