Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer.

ABSTRACT: Prostate cancer (PCa) is the second most common solid tumor for cancer related deaths in American men. Genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with the increased risk of PCa. Because most of the susceptibility SNPs are located in noncoding regions, little is known about their functional mechanisms. We hypothesize that functional SNPs reside in cell type-specific regulatory elements that mediate the binding of critical transcription factors (TFs), which in turn result in changes in target gene expression. Using PCa-specific functional genomics data, here we identify 38 regulatory candidate SNPs and their target genes in PCa. Through risk analysis by incorporating gene expression and clinical data, we identify 6 target genes (Z

SUBMITTER: Jin HJ 

PROVIDER: S-EPMC5338917 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature