Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study.

ABSTRACT: The numerous increasing use of carbon nanotubes (CNTs) derived from nanotechnology has raised concerns about their biosafety and potential toxicity. CNTs cause immunologic dysfunction and limit the application of CNTs in biomedicine. The immunological responses induced by pristine multi-walled carbon nanotubes (p-MWCNTs) and PEGylated multi-walled carbon nanotubes (MWCNTs-PEG) on BALB/c mice via an intravenous administration were investigated. The results reflect that the p-MWCNTs induced significant increases in spleen, thymus, and lung weight. Mice treated with p-MWCNTs showed altered lymphocyte populations (CD3⁺, CD4⁺, CD8⁺, and CD19⁺) in peripheral blood and increased serum IgM and IgG levels, and splenic macrophage ultrastructure indicated m

SUBMITTER: Zhang T 

PROVIDER: S-EPMC5339008 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature