Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs.

ABSTRACT: Positive affect denotes a state of pleasurable engagement with the environment eliciting positive emotion such as contentment, enthusiasm or happiness. Positive affect is associated with favorable psychological, physical and economic outcomes in many longitudinal studies. With a heritability of ⩽64%, positive affect is substantially influenced by genetic factors; however, our understanding of genetic pathways underlying individual differences in positive affect is still limited. Here, through a genome-wide association study of positive affect in African-American participants, we identify a single-nucleotide polymorphism, rs322931, significantly associated with positive affect at P<5 × 10^-8, and replicate this association in another cohort. Furthermore, we show that the minor all

SUBMITTER: Wingo AP 

PROVIDER: S-EPMC5339071 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature