Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees.

ABSTRACT: Hepatitis C virus (HCV) infections represent a global health problem and are a major contributor to end-stage liver disease including cirrhosis and hepatocellular carcinoma. An improved understanding of the parameters involved in disease progression is needed to develop better therapies and diagnostic markers of disease manifestation. To better understand the dynamics of host gene expression resulting from persistent virus infection, DNA microarray analyses were conducted on livers from 10 chimpanzees persistently infected with HCV. A total of 162 genes were differentially regulated in chronically infected animals compared to uninfected controls. Many genes exhibited a remarkable consistency in changes in expression in the 10 chronically infected animals. A second method of analysis identi

SUBMITTER: Bigger CB 

PROVIDER: S-EPMC533929 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature