Characterization of the Highly Prevalent Regulatory CD24^hiCD38^hi B-Cell Population in Human Cord Blood.

ABSTRACT: The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19⁺CD24^hiCD38^hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different conditions, including pregnancy. Breg have still not been well characterized in umbilical cord blood, where we hypothesize that they are pivotal in the achievement of tolerance. We studied CD19⁺CD24^hiCD38^hi Breg in healthy umbilical cord blood (hUCB) compared to healthy peripheral adult blood (hAPB). Total numbers of Breg were increased in hUCB compared to hAPB (34.39 vs. 9.49%; p = 0.0002), especially in the

SUBMITTER: Esteve-Sole A 

PROVIDER: S-EPMC5339297 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature