The metabolic impact of extracellular nitrite on aerobic metabolism of Paracoccus denitrificans.

ABSTRACT: Nitrite, in equilibrium with free nitrous acid (FNA), can inhibit both aerobic and anaerobic growth of microbial communities through bactericidal activities that have considerable potential for control of microbial growth in a range of water systems. There has been much focus on the effect of nitrite/FNA on anaerobic metabolism and so, to enhance understanding of the metabolic impact of nitrite/FNA on aerobic metabolism, a study was undertaken with a model denitrifying bacterium Paracoccus denitrificans PD1222. Extracellular nitrite inhibits aerobic growth of P. denitrificans in a pH-dependent manner that is likely to be a result of both nitrite and free nitrous acid (pK_a = 3.25) and subsequent reactive nitrogen oxides generated from the intracellular passage of FNA into P. deni

SUBMITTER: Hartop KR 

PROVIDER: S-EPMC5339346 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature