Transcriptome Analysis of Monozygotic Twin Brothers with Childhood Primary Myelofibrosis.

ABSTRACT: Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder in human bone marrow. Over 50% of patients with myelofibrosis have mutations in JAK2, MPL, or CALR. However, these mutations are rarely detected in children, suggesting a difference in the pathogenesis of childhood PMF. In this study, we investigated the response to drug treatment of a monozygotic twin pair with typical childhood PMF. The twin exhibited different clinical outcomes despite following the same treatment regimen. The transcriptomic profiles of patient samples after drug treatment (E2 and Y2) were significantly different between the twin pair, which is consistent with the observation that the drug treatment was effective only in the younger brother, despite the twin being genetically identical. Bioinformatics

SUBMITTER: Ding N 

PROVIDER: S-EPMC5339410 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature