Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling.

ABSTRACT: Hydrogen peroxide (H₂O₂) is a key signaling agent. Its best characterized signaling actions in mammalian cells involve the early oxidation of thiols in cytoplasmic phosphatases, kinases and transcription factors. However, these redox targets are orders of magnitude less H₂O₂-reactive and abundant than cytoplasmic peroxiredoxins. How can they be oxidized in a signaling time frame? Here we investigate this question using computational reaction-diffusion models of H₂O₂ signaling. The results show that at H₂O₂ supply rates commensurate with mitogenic signaling a H₂O₂ concentration gradient with a length scale of a few tenths of μm is established. Even near the supply sites H₂

SUBMITTER: Travasso RDM 

PROVIDER: S-EPMC5339411 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature