Decreased S100B expression in chronic liver diseases.

ABSTRACT:

Background/aims

Hepatic innervation in liver diseases is not fully understood. We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively.

Methods

Liver specimens were obtained from 70 subjects (three controls, and 32 chronic hepatitis B, 14 chronic hepatitis C, 14 liver cirrhosis, and seven hepatocellular carcinoma patients). The hepatic nerve density was calculated based on immunohistochemical staining of S100B protein in the portal tracts and hepatic lobules. S100B mRNA levels were semi-quantitatively assessed as the S100B/glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA ratio.

Results

The densities of the hepatic nerves in portal tracts of chron

SUBMITTER: Baik SJ 

PROVIDER: S-EPMC5339465 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature