Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity.

ABSTRACT: Maintaining stemness of leukemic stem cells (LSCs) and reciprocal interactions between leukemia and stromal cells support leukemic progression and resistance to chemotherapy. Targeting the niche-based microenvironment is thus a new approach for leukemia therapy. Cordycepin is an analogue of adenosine and has been suggested to possess anti-leukemia properties. However, whether cordycepin influences association of leukemia and mesenchymal stromal cells has never been investigated. Here we show that cordycepin reduces CD34⁺CD38^- cells in U937 and K562 cells and induces Dkk1 expression via autocrine and paracrine regulation in leukemia and mesenchymal stromal/stem cells (MSCs). Cordycepin suppresses cell attachment of leukemia with MSCs and downregulates N-cadherin in leu

SUBMITTER: Liang SM 

PROVIDER: S-EPMC5339716 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature