Autaptic Connections Shift Network Excitability and Bursting.

ABSTRACT: We examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal activity, we study how autaptic connections affect activity patterns, and evaluate if controllability significantly affects changes in bursting from autaptic connections. Adding more autaptic connections to excitatory neurons increased the number of spiking events and the number of network-wide bursts. We observed excitatory synapses contributed more to bursting behavior than inhibitory synapses. We evaluated if neurons with high average controllability, predicted to push the network into easily achievable states, affected bursting behavior differently than neurons with high modal controllability, thought to influence the networ

SUBMITTER: Wiles L 

PROVIDER: S-EPMC5339801 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature