YTHDF3 facilitates translation and decay of N⁶-methyladenosine-modified RNA.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and tissue development. It regulates multiple steps throughout the RNA life cycle including RNA processing, translation, and decay, via the recognition by selective binding proteins. In the cytoplasm, m⁶A binding protein YTHDF1 facilitates translation of m⁶A-modified mRNAs, and YTHDF2 accelerates the decay of m⁶A-modified transcripts. The biological function of YTHDF3, another cytoplasmic m⁶A binder of the YTH (YT521-B homology) domain family, remains unknown. Here, we report that YTHDF3 promotes protein synthesis in synergy with YTHDF1, and affects methylated mRNA decay

SUBMITTER: Shi H 

PROVIDER: S-EPMC5339834 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature