Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization.

ABSTRACT: The rising number of patients needing renal replacement therapy, alongside the significant clinical and economic limitations of current therapies, creates an imperative need for new strategies to treat kidney diseases. Kidney bioengineering through the production of acellular scaffolds and recellularization with stem cells is one potential strategy. While protocols for obtaining organ scaffolds have been developed successfully, scaffold recellularization is more challenging. We evaluated the potential of in vivo and in vitro kidney scaffold recellularization procedures. Our results show that acellular scaffolds implanted in rats cannot be repopulated with host cells, and in vitro recellularization is necessary. However, we obtained very limited and inconsistent cell seeding when using diff

SUBMITTER: Remuzzi A 

PROVIDER: S-EPMC5339865 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature