Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos.

ABSTRACT: Thyroid hormones are essential for normal brain development in vertebrates. In humans, abnormal maternal thyroid hormone levels during early pregnancy are associated with decreased offspring IQ and modified brain structure. As numerous environmental chemicals disrupt thyroid hormone signalling, we questioned whether exposure to ubiquitous chemicals affects thyroid hormone responses during early neurogenesis. We established a mixture of 15 common chemicals at concentrations reported in human amniotic fluid. An in vivo larval reporter (GFP) assay served to determine integrated thyroid hormone transcriptional responses. Dose-dependent effects of short-term (72 h) exposure to single chemicals and the mixture were found. qPCR on dissected brains showed significant changes in thyroid hormone-rel

SUBMITTER: Fini JB 

PROVIDER: S-EPMC5339866 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature