Stereotactic spine radiosurgery: Review of safety and efficacy with respect to dose and fractionation.

ABSTRACT:

Background

Stereotactic body radiotherapy (SBRT) is an emerging treatment option for spinal metastases with demonstrated efficacy in the upfront, postoperative, and re-treatment settings, as well as for tumor histologies considered radioresistant. Uncertainty exists regarding the optimal dose and fractionation schedule, with single and multifraction regimens commonly utilized.

Methods

A literature search of the PubMed and Medline databases was conducted to identify papers specific to spine SBRT and the effect of varying dose/fractionation regimens on outcomes. Bibliographies of relevant papers were searched for further references, and international spine SBRT experts were consulted.

Results

Local control rates generally exceed 80% at 1 year, while high rates of pain c

SUBMITTER: Huo M 

PROVIDER: S-EPMC5339918 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature