Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.

ABSTRACT:

Background

The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from approximately 24,000 adult volunteers across Scotland. Although data collection was cross-sectional, GS:SFHS became a prospective cohort due to of the ability to link to routine Electronic Health Record (EHR) data. Over 20,000 participants were selected for genotyping using a large genome-wide array.

Methods

GS:SFHS was analysed using genome-wide association studies (GWAS) to test the effects of a large spectrum of variants, imputed using the Haplotype Research Consortium (HRC) dataset, on medically relevant traits measured directly or obtained from EHRs. The HRC dataset is the lar

SUBMITTER: Nagy R 

PROVIDER: S-EPMC5339960 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature