Optical coherence tomography-based observation of the natural history of drusenoid lesion in eyes with dry age-related macular degeneration.

ABSTRACT:

Purpose

To use spectral domain optical coherence tomography (SD-OCT) to investigate risk factors predictive for the development of atrophy of drusenoid lesions (DLs) (drusen and drusenoid pigment epithelium detachment) in eyes with non-neovascular age-related macular degeneration (NNVAMD).

Design

Cohort study.

Participants

Forty-one eyes from 29 patients with NNVAMD.

Methods

Patients with NNVAMD who underwent registered SD-OCT imaging over a minimum period of 6 months were reviewed. Drusenoid lesions that were accompanied by new atrophy onset at 6 months or last follow-up (FUL) were further analyzed. Detailed lesion change was described throughout the study period. Odds ratios (ORs) and risk for new local atrophy onset were calculated.

Main outcome measures<

SUBMITTER: Ouyang Y 

PROVIDER: S-EPMC5340146 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature