Effects of Terminal Sterilization on PEG-Based Bioresorbable Polymers Used in Biomedical Applications.

ABSTRACT: The effects of ethylene oxide (EO), vaporized hydrogen peroxide (VHP), gamma (γ) radiation, and electron-beam (E-beam) on the physiochemical and morphological properties of medical device polymers are investigated. Polymers with ether, carbonate, carboxylic acid, amide and ester functionalities are selected from a family of poly(ethylene glycol) (PEG) containing tyrosine-derived polycarbonates (TyrPCs) to include slow, medium, fast, and ultrafast degrading polymers. Poly(lactic acid) (PLA) is used for comparison. Molecular weight (M_w) of all tested polymers decreases upon gamma and E-beam, and this effect becomes more pronounced at higher PEG content. Gamma sterilization increases the glass transition temperature of polymers with high PEG content. EO esterifies the carbox

SUBMITTER: Bhatnagar D 

PROVIDER: S-EPMC5340269 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature