Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring.

ABSTRACT: Paternal environmental conditions can influence phenotypes in future generations, but it is unclear whether offspring phenotypes represent specific responses to particular aspects of the paternal exposure history, or a generic response to paternal 'quality of life'. Here, we establish a paternal effect model based on nicotine exposure in mice, enabling pharmacological interrogation of the specificity of the offspring response. Paternal exposure to nicotine prior to reproduction induced a broad protective response to multiple xenobiotics in male offspring. This effect manifested as increased survival following injection of toxic levels of either nicotine or cocaine, accompanied by hepatic upregulation of xenobiotic processing genes, and enhanced drug clearance. Surprisingly, this protective

SUBMITTER: Vallaster MP 

PROVIDER: S-EPMC5340528 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature