Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats.

ABSTRACT:

Background/objectives

The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a shared etiology. In conjunction with defects in hormonal and inflammatory states, obesity and T2D are also characterized by dysbiosis.

Methods

We have recently described the beneficial effects of duodenal nutrient exclusion, as induced by the duodenal endoluminal sleeve (DES); including body weight loss, prevented fat mass accumulation, and improved glucose tolerance in the ZDF rat, a rodent model of obesity and type-2 diabetes (T2D). To assess the relative role of DES on hindgut micr

SUBMITTER: Kim T 

PROVIDER: S-EPMC5340580 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature