NLRX1 Regulates Effector and Metabolic Functions of CD4⁺ T Cells.

ABSTRACT: Nucleotide oligomerization domain-like receptor X1 (NLRX1) has been implicated in viral response, cancer progression, and inflammatory disorders; however, its role as a dual modulator of CD4⁺ T cell function and metabolism has not been defined. The loss of NLRX1 results in increased disease severity, populations of Th1 and Th17 cells, and inflammatory markers (IFN-γ, TNF-α, and IL-17) in mice with dextran sodium sulfate-induced colitis. To further characterize this phenotype, we used in vitro CD4⁺ T cell-differentiation assays and show that NLRX1-deficient T cells have a greater ability to differentiate into an inflammatory phenotype and possess greater proliferation rates. Further, NLRX1^-/- cells have a decreased responsiveness to immune checkpoint pathway

SUBMITTER: Leber A 

PROVIDER: S-EPMC5340590 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature