Exposure to a Social Stressor Induces Translocation of Commensal Lactobacilli to the Spleen and Priming of the Innate Immune System.

ABSTRACT: Studies have shown that exposure to psychological stressors leads to inflammation throughout the body. This has been widely studied using social disruption (SDR), a social stressor that involves repeated social defeat in subordinate mice. Exposure to SDR increases serum cytokine levels, results in accumulation of spleen CD11b⁺ myeloid cells, and primes macrophages for increased cytokine and microbicidal activity. Our previous studies showed that intestinal microbes are necessary for SDR-enhancement of innate immunity. In this study, we show that SDR increases spleen CD11b⁺Ly6C^intermLy6G⁺ neutrophil and CD11b⁺Ly6C^hiLy6G^-monocyte numbers compared with control mice. Further, we found that neutrophils and monocytes fr

SUBMITTER: Lafuse WP 

PROVIDER: S-EPMC5340647 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature