Measuring and modelling the effects of systematic non-adherence to mass drug administration.

ABSTRACT: It is well understood that the success or failure of a mass drug administration campaign critically depends on the level of coverage achieved. To that end coverage levels are often closely scrutinised during campaigns and the response to underperforming campaigns is to attempt to improve coverage. Modelling work has indicated, however, that the quality of the coverage achieved may also have a significant impact on the outcome. If the coverage achieved is likely to miss similar people every round then this can have a serious detrimental effect on the campaign outcome. We begin by reviewing the current modelling descriptions of this effect and introduce a new modelling framework that can be used to simulate a given level of systematic non-adherence. We formalise the likelihood that people ma

SUBMITTER: Dyson L 

PROVIDER: S-EPMC5340860 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature