Transcriptome Remodeling of Acinetobacter baumannii during Infection and Treatment.

ABSTRACT: Acinetobacter baumannii is an increasingly common multidrug-resistant pathogen in health care settings. Although the genetic basis of antibiotic resistance mechanisms has been extensively studied, much less is known about how genetic variation contributes to other aspects of successful infections. Genetic changes that occur during host infection and treatment have the potential to remodel gene expression patterns related to resistance and pathogenesis. Longitudinal sets of multidrug-resistant A. baumannii isolates from eight patients were analyzed by RNA sequencing (RNA-seq) to identify differentially expressed genes and link them to genetic changes contributing to transcriptional variation at both within-patient and population levels. The number of differentially expressed g

SUBMITTER: Wright MS 

PROVIDER: S-EPMC5340874 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature