Presynaptic gain control by endogenous cotransmission of dopamine and GABA in the olfactory bulb.

ABSTRACT: In the olfactory bulb, lateral inhibition mediated by local juxtaglomerular interneurons has been proposed as a gain control mechanism, important for decorrelating odorant responses. Among juxtaglomerular interneurons, short axon cells are unique as dual-transmitter neurons that release dopamine and GABA. To examine their intraglomerular function, we expressed channelrhodopsin under control of the DAT-cre promoter and activated olfactory afferents within individual glomeruli. Optical stimulation of labeled cells triggered endogenous dopamine release as measured by cyclic voltammetry and GABA release as measured by whole cell GABA_A receptor currents. Activation of short axon cells reduced the afferent presynaptic release probability via D₂ and GABA_B receptor

SUBMITTER: Vaaga CE 

PROVIDER: S-EPMC5340883 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature