Detection of Circulating Tumour Cells in Urothelial Cancers and Clinical Correlations: Comparison of Two Methods.

ABSTRACT: Circulating tumour cells (CTC) are identified exploiting their protein/gene expression patterns or distinct size compared to blood cells. Data on CTC in bladder cancer (BC) are still scarce. We comparatively analyzed CTC enrichment by AdnaTest ProstateCancerSelect (AT) and ScreenCell®Cyto (SC) kits, combined with identification by EPCAM, MUC1, and ERBB2 expression and by cytological criteria, respectively, in 19 nonmetastatic (M₀) and 47 metastatic (M₊) BC patients, at baseline (T₀) and during treatment (T₁). At T₀, CTC positivity rates by AT were higher in M₊ compared to M₀ cases (57.4% versus 25%, p = 0.041). EPCAM was detected in 75% o

SUBMITTER: Fina E 

PROVIDER: S-EPMC5340956 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature