Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study.

ABSTRACT: Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals. The IL-12A and EBI3 polymorphisms were determined in 1162 patients with premature CAD and 873 controls. Under different models, the EBI3 rs428253 (OR = 0.831, P_add = 0.036; OR = 0.614, P_rec = 0.033; OR = 0.591, P_cod2 = 0.027) and IL-12A rs2243115 (OR = 0.674, P_add = 0.010; OR = 0.676, P_dom = 0.014; OR = 0.698, P_het = 0.027;

SUBMITTER: Posadas-Sanchez R 

PROVIDER: S-EPMC5340958 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature