Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling.

ABSTRACT: Erythro-myeloid progenitors (EMPs) were recently described to arise from the yolk sac endothelium, just prior to vascular remodeling, and are the source of adult/post-natal tissue resident macrophages. Questions remain, however, concerning whether EMPs differentiate directly from the endothelium or merely pass through. We provide the first evidence in vivo that EMPs can emerge directly from endothelial cells (ECs) and demonstrate a role for these cells in vascular development. We find that EMPs express most EC markers but late EMPs and EMP-derived cells do not take up acetylated low-density lipoprotein (AcLDL), as ECs do. When the endothelium is labelled with AcLDL before EMPs differentiate, EMPs and EMP-derived cells arise that are AcLDL⁺. If AcLDL is injected after the onset o

SUBMITTER: Kasaai B 

PROVIDER: S-EPMC5341067 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature