DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.

ABSTRACT:

Background

Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum. DCYTB is also a member of a 16-gene iron regulatory gene signature (IRGS) that predicts metastasis-free survival in breast cancer patients. To better understand the relationship between DCYTB and breast cancer, we explored in detail the prognostic significance and molecular function of DCYTB in breast cancer.

Methods

The prognostic significance of DCYTB expression was evaluated using publicly available microarray data. Signaling Pathway Impact Analysis (SPIA) of microarray data was used to identify potential novel functions of DCYTB. The role of DCYTB was assessed using immunohistochemistry

SUBMITTER: Lemler DJ 

PROVIDER: S-EPMC5341190 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature