Trans-ethnic follow-up of breast cancer GWAS hits using the preferential linkage disequilibrium approach.

ABSTRACT: Leveraging population-distinct linkage equilibrium (LD) patterns, trans-ethnic follow-up of variants discovered from genome-wide association studies (GWAS) has proved to be useful in facilitating the identification of bona fide causal variants. We previously developed the preferential LD approach, a novel method that successfully identified causal variants driving the GWAS signals within European-descent populations even when the causal variants were only weakly linked with the GWAS-discovered variants. To evaluate the performance of our approach in a trans-ethnic setting, we applied it to follow up breast cancer GWAS hits identified mostly from populations of European ancestry in African Americans (AA). We evaluated 74 breast cancer GWAS variants in 8,315 AA women from the African America

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC5341253 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature