Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States.

ABSTRACT:

Background

This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years.

Methods

This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed.

Results

Approximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boys and >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin

SUBMITTER: Giudici KV 

PROVIDER: S-EPMC5341348 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature