MiR-29 Regulates Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa.

ABSTRACT: Recessive dystrophic epidermolysis bullosa (RDEB) is a complex inherited skin disorder caused by loss-of-function mutations in the COL7A1 gene. For an effective treatment of this disorder to be realized, both a thorough understanding of the regulation of COL7A1 and an understanding of the underlying nature of the complications of RDEB are needed. Currently, both posttranscriptional regulation of COL7A1 and the underlying causes of fibrosis in RDEB patients are poorly understood. Here, we describe a mechanism of regulation, to our knowledge previously unknown, by which micro RNA-29 (miR-29) regulates COL7A1 in a complex network: both directly through targeting its 3' untranslated region at two distinct seed regions and indirectly through targeting an essential transcription factor required

SUBMITTER: Vanden Oever M 

PROVIDER: S-EPMC5341382 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature