Population-specific association between ABCG2 variants and tophaceous disease in people with gout.

ABSTRACT:

Background

Tophi contribute to musculoskeletal disability, joint damage and poor health-related quality of life in people with gout. The aim of this study was to examine the role of SLC2A9 and ABCG2 variants in tophaceous disease in people with gout.

Methods

Participants (n = 1778) with gout fulfilling the 1977 American Rheumatism Association (ARA) classification criteria, who were recruited from primary and secondary care, attended a detailed study visit. The presence of palpable tophi was recorded. SLC2A9 rs11942223, ABCG2 rs2231142 and ABCG2 rs10011796 were genotyped. Data were analysed according to tophus status.

Results

Compared to participants without tophi, those with tophi were older, had longer disease duration and higher serum creatinine, and were more likel

SUBMITTER: He W 

PROVIDER: S-EPMC5341474 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature