The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro.

ABSTRACT:

Background and purpose

Liver diseases are mostly accompanied by inflammation and hepatocyte death. Therapeutic approaches targeting both hepatocyte injury and inflammation are not available. Natural compounds are considered as potential treatment for inflammatory liver diseases. Hesperetin, a flavonoid component of citrus fruits, has been reported to have anti-inflammatory properties. The aim of this study was to evaluate the cytoprotective and anti-inflammatory properties of hesperetin both in vitro and in models of fulminant hepatitis.

Experimental approach

Apoptotic cell death and inflammation were induced in primary cultures of rat hepatocytes by bile acids and cytokine mixture respectively. Apoptosis was quantified by caspase-3 activity and necrosis by LDH release. The

SUBMITTER: Bai X 

PROVIDER: S-EPMC5341490 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature