Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy.

ABSTRACT:

Purpose

We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes.

Methods

Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank. An additional 197 Caucasian patients with diabetes (98 with DR) were enrolled from the Vanderbilt Eye Institute (VEI). We tested for an association between European mitochondrial haplogroups and DR status.

Results

SUBMITTER: Bregman JA 

PROVIDER: S-EPMC5341621 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature