Aggressive temperament predicts ethanol self-administration in late adolescent male and female rhesus macaques.

ABSTRACT:

Rationale

Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relation to future or prior ethanol intake.

Objective

The objective of the study was to test the association between temperament at baseline with future ethanol self-administration in late adolescent male (n = 21) and female (n = 11) rhesus monkeys.

Methods

Shortly after entering the laboratory and before exposure to ethanol, the Human Intruder Test (HIT) and the Novel Object Test (NOT) were used to determine baseline anxious-like and aggressive-like behavior

SUBMITTER: McClintick MN 

PROVIDER: S-EPMC5341689 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature