Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory.

ABSTRACT: CD8 T cell memory is characterized by rapid recall of effector function, increased proliferation, and reduced activation requirements. Despite the extensive functional characterization, the molecular mechanisms that facilitate these enhanced properties are not well characterized. In this study, the assay for transposase-accessible chromatin sequencing was employed to map the cis-regulatory elements in CD8 T cells responding to acute and chronic lymphocytic choriomeningitis virus infections. Integration of chromatin accessibility profiles with gene expression data identified unique regulatory modules that were enriched for distinct combinations of transcription factor-binding motifs. Memory CD8 T cells displayed a chromatin accessibility structure that was absent from other acute and

SUBMITTER: Scharer CD 

PROVIDER: S-EPMC5341694 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature