Plasma carotenoids and the risk of premalignant breast disease in women aged 50 and younger: a nested case-control study.

ABSTRACT:

Purpose

To examine the association of plasma carotenoids, micronutrients in fruits, and vegetables, with risk of premalignant breast disease (PBD) in younger women.

Methods

Blood samples were collected at the Siteman Cancer Center between 2008 and 2012 from 3537 women aged 50 or younger with no history of cancer or PBD. The analysis included 147 participants diagnosed with benign breast disease or breast carcinoma in situ during a 27-month follow-up and 293 controls. Cases and controls were matched on age, race/ethnicity, and date of and fasting status at blood draw. Plasma carotenoids were quantified. We used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) and linear regression to assess racial differences in plasma carotenoids.

Resu

SUBMITTER: Cohen K 

PROVIDER: S-EPMC5341742 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature