Rapid visualization of nonmelanoma skin cancer.

ABSTRACT:

Background

Mohs micrographic surgery examines all margins of the resected sample and has a 99% cure rate. However, many nonmelanoma skin cancers (NMSCs) are not readily amenable to Mohs micrographic surgery. This defines an unmet clinical need to assess the completeness of non-Mohs micrographic surgery resections during surgery to prevent re-excision/recurrence.

Objective

We sought to examine the utility of quenched activity-based probe imaging to discriminate cancerous versus normal-appearing skin tissue.

Methods

The quenched activity-based probe GB119 was applied to NMSC excised from 68 patients. We validated activation of the probe for hematoxylin-eosin-confirmed cancerous tissue versus normal-appearing skin tissue.

Results

Topical application of the probe d

SUBMITTER: Walker E 

PROVIDER: S-EPMC5341746 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature