Ontology highlight
ABSTRACT:
SUBMITTER: McCarthy RR
PROVIDER: S-EPMC5341770 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature microbiology 20170306
Pseudomonas aeruginosa is a Gram-negative bacterial pathogen associated with acute and chronic infections. The universal cyclic-di-GMP second messenger is instrumental in the switch from a motile lifestyle to resilient biofilm as in the cystic fibrosis lung. The SadC diguanylate cyclase is associated with this patho-adaptive transition. Here, we identify an unrecognized SadC partner, WarA, which we show is a methyltransferase in complex with a putative kinase, WarB. We established that WarA bind ...[more]