On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer.

ABSTRACT: Altered metabolism in tumor cells has been a focus of cancer research for as long as a century but has remained controversial and vague due to an inhomogeneous overall picture. Accumulating genomic, metabolomic, and lastly panomic data as well as bioenergetics studies of the past few years enable a more comprehensive, systems-biologic approach promoting deeper insight into tumor biology and challenging hitherto existing models of cancer bioenergetics. Presenting a compendium on breast cancer-specific metabolome analyses performed thus far, we review and compile currently known aspects of breast cancer biology into a comprehensive network, elucidating previously dissonant issues of cancer metabolism. As such, some of the aspects critically discussed in this review include the dynamic interp

SUBMITTER: Penkert J 

PROVIDER: S-EPMC5341901 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature