Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis.

ABSTRACT:

Objective

The role of Dicer in the prognosis of cancer patients remains controversial. This systematic review is attempted to assess the influence of Dicer as a prognostic predictor for survival in diverse types of cancers.

Methods

Studies were selected as candidates if they published an independent evaluation of Dicer expression level together with the correlation with prognosis in cancers. Random-effect model was applied in this meta-analysis. Heterogeneity between studies was assessed by Q-statistic with P < 0.10 to be statistically significant. Publication bias was investigated using funnel plot and test with Begg's and Egger's test. P < 0.05 was regarded as statistically significant.

Results

24 of 44 articles revealed low Dicer status as a predictor of poor progn

SUBMITTER: Shan W 

PROVIDER: S-EPMC5341936 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature