Asporin enhances colorectal cancer metastasis through activating the EGFR/src/cortactin signaling pathway.

ABSTRACT: Asporin has been implicated as an oncogene in various types of human cancers; however, the roles of asporin in the development and progression of colorectal cancer (CRC) have not yet been determined. With clinical samples, we found that asporin was highly expressed in CRC tissues compared to adjacent normal tissues and the asporin expression levels were significantly associated with lymph node metastasis status and TNM stage of the patients. Through knockdown of asporin in CRC cell lines RKO and SW620 or overexpression of asporin in cell lines HT-29 and LoVo, we found that asporin could enhance wound healing, migration and invasion abilities of the CRC cells. Further more, with the human umbilical vein endothelial cells (HUVECs) tube formation assays and the xenograft model, we found that

SUBMITTER: Wu H 

PROVIDER: S-EPMC5341987 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature